Osteoarthritis of the knee (gonarthrosis) is the most common cause of chronic knee pain. The essence of the degeneration is the degradation of the articular cartilage, leading to its gradual abrasion until the bone surface is exposed. Gonarthrosis is the result of the combination of biological factors related to the reduced quality of cartilage and mechanical factors related to acute injuries and chronic overload of the knee. Inflammatory factors in the course of systemic diseases are also important.
The degenerative process covers not only the articular cartilage, but later also the subcartilage layer of the bones, the joint capsule and ligaments, leading to deformation and painful limitation of mobility in the knee joint. The result of the disease is impaired gait and reduced quality of life. Treatment is mainly based on the elimination or reduction of risk factors accelerating the degeneration of the knee joint. In the advanced stage of the disease, it is necessary to replace the damaged joint with an artificial knee prosthesis.

